Research

“How small a thought it takes to fill a whole life!” — Ludwig Wittgenstein

Recent Publications

[J5] Neuronal wiring diagram of an adult brain.
Sven Dorkenwald, Arie Matsliah, Amy R. Sterling, Philipp Schlegel, Szi-chieh Yu, Claire E. McKellar, Albert Lin, Marta Costa, Katharina Eichler, Yijie Yin, Will Silversmith, Casey Schneider-Mizell, Chris S. Jordan, Derrick Brittain, Akhilesh Halageri, Kai Kuehner, Oluwaseun Ogedengbe, Ryan Morey, Jay Gager, Krzysztof Kruk, Eric Perlman, Runzhe Yang, David Deutsch, Doug Bland, Marissa Sorek, Ran Lu, Thomas Macrina, Kisuk Lee, J. Alexander Bae, Shang Mu, Barak Nehoran, Eric Mitchell, Sergiy Popovych, Jingpeng Wu, Zhen Jia, Manuel A. Castro, Nico Kemnitz, Dodam Ih, Alexander Shakeel Bates, Nils Eckstein, Jan Funke, Forrest Collman, Davi D. Bock, Gregory S. X. E. Jefferis, H. Sebastian Seung*, Mala Murthy* & The FlyWire Consortium.
Nature, 634, pages 124–138, October 2024.
[ AI/ML] [ Neuro] [ Article | Bib｜ FlyWire | Cover Feature]
[J4] Network statistics of the whole-brain connectome of Drosophila.
Albert Lin*, Runzhe Yang*, Sven Dorkenwald, Arie Matsliah, Amy R. Sterling, Philipp Schlegel, Szi-chieh Yu, Claire E. McKellar, Marta Costa, Katharina Eichler, Alexander Shakeel Bates, Nils Eckstein, Jan Funke, Gregory S. X. E. Jefferis & Mala Murthy.
Nature, 634, pages 153–165, October 2024.
[ Neuro] [ Stats] [ Article | Bib｜ FlyWire | Code ]
[J3] Whole-brain annotation and multi-connectome cell typing of Drosophila.
Philipp Schlegel, Yijie Yin, Alexander S. Bates, Sven Dorkenwald, Katharina Eichler, Paul Brooks, Daniel S. Han, Marina Gkantia, Marcia dos Santos, Eva J. Munnelly, Griffin Badalamente, Laia Serratosa Capdevila, Varun A. Sane, Alexandra M. C. Fragniere, Ladann Kiassat, Markus W. Pleijzier, Tomke Stürner, Imaan F. M. Tamimi, Christopher R. Dunne, Irene Salgarella, Alexandre Javier, Siqi Fang, Eric Perlman, Tom Kazimiers, Sridhar R. Jagannathan, Arie Matsliah, Amy R. Sterling, Szi-chieh Yu, Claire E. McKellar, FlyWire Consortium, Marta Costa, H. Sebastian Seung, Mala Murthy, Volker Hartenstein, Davi D. Bock* & Gregory S. X. E. Jefferis*.
Nature, 634, pages 139–152, October 2024.
[ Neuro] [ Article | Bib｜ FlyWire ]
[M11] LLMs are superior feedback providers: bootstrapping reasoning for lie detection with self-generated feedback.
Tanushree Banerjee, Richard Zhu, Runzhe Yang, Karthik Narasimhan. August 2024.
[ AI/ML] [ NLP] [ arXiv | Bib｜ Kaggle Dataset ]
[C9] COLLIE: Systematic construction of constrained text generation tasks.
Shunyu Yao*, Howard Chen*, Austin W. Hanjie*, Runzhe Yang*, Karthik Narasimhan.
In proceedings of the 12th International Conference on Learning Representations (ICLR 2024), Vienna, Austria, May 2024.
[ NLP] [ Article | Bib｜ Code ]
[J2] Cyclic structure with cellular precision in a vertebrate sensorimotor neural circuit.
Runzhe Yang, Ashwin Vishwanathan, Jingpeng Wu, Nico Kemnitz, Dodam Ih, Nicholas Turner, Kisuk Lee, Ignacio Tartavull, William M. Silversmith, Chris S. Jordan, Celia David, Doug Bland, Amy Sterling, Mark S. Goldman, Emre R.F. Aksay, H. Sebastian Seung, the Eyewirers.
Current Biology, Volume 33, Issue 11, June 2023
[ Neuro] [ Stats] [ Article | Bib ]

[A3] Neuronal circuits for robust online fixed-Point detection.
Runzhe Yang, David Lipshutz, Tiberiu Tesileanu, Johannes Friedrich, Dmitri Chklovskii.
Computational and Systems Neuroscience (COSYNE 2023), Montreal, Canada, March 2023.
[ AI/ML] [ Abstract | Poster]
[C8] DataMUX: Data multiplexing for neural networks.
Vishvak Murahari, Carlos Jimenez, Runzhe Yang, Karthik Narasimhan.
In proceedings of the 36th Annual Conference on Neural Information Processing Systems (NeurIPS 2022), New Orleans, USA, November 2022.
[ AI/ML] [ Article | Bib ｜ Code | Bell Labs Prize ]
[J1] Reconstruction of neocortex: Organelles, compartments, cells, circuits, and activity.
Nicholas Turner*, Thomas Macrina*, Alexander Bae*, Runzhe Yang*, Alyssa Wilson*, Casey Schneider-Mizell*, Kisuk Lee*, Ran Lu*, Jingpeng Wu*, Agnes Bodor*, Adam Bleckert*, Derrick Brittain*, Emmanouil Froudarakis*, Sven Dorkenwald*, Forrest Collman*, Nico Kemnitz* (equal contribution), …, Sebastian Seung.
Cell, Volume 185, Issue 6, March 2022
[ Neuro] [ Stats] [ Article | Bib | MICrONS Explorer ]
[C7] Improving dialog systems for negotiation with personality modeling.
Runzhe Yang*, Jingxiao Chen* (equal contribution) and Karthik Narasimhan.
In proceedings of the 59th Annual Meeting of the Association for Computational Linguistics (ACL 2021), Bangkok, Thailand, August 2021.
[ AI/ML] [ NLP] [ Article | Bib ｜ Code ]
[M8] Functional connectomics spanning multiple areas of mouse visual cortex.
MICrONS Consortium et al. July 2021.
[ Neuro] [ bioRxiv | Bib | News ]
[A2] Unsupervised feature discovery by neural networks with disynaptic recurrent inhibition.
Runzhe Yang, Kyle Luther, H. Sebastian Seung
Selected talk at the From Neuroscience to Artificially Intelligent Systems conference (NAISys 2020), Online, November 2020.
[ AI/ML] [ Neuro] [ Abstract | Talk ]
[M7] Modularity and neural coding from a brainstem synaptic wiring diagram.
Ashwin Vishwanathan, Alexandro D. Ramirez*, Jingpeng Wu* (equal contribution), Alex Sood, Runzhe Yang, Nico Kemnitz, Dodam Ih, Nicholas Turner, Kisuk Lee, Ignacio Tartavull, William M. Silversmith, Chris S. Jordan, Celia David, Doug Bland, Mark S. Goldman, Emre R. F. Aksay, H. Sebastian Seung, the EyeWirers. October 2020.
[ Neuro] [ bioRxiv | Bib ]

[C6] A Generalized algorithm for multi-objective reinforcement learning and policy adaptation.
Runzhe Yang, Xingyuan Sun and Karthik Narasimhan.
In proceedings of the 33rd Annual Conference on Neural Information Processing Systems (NeurIPS 2019), Vancouver, Canada, December 2019.
[ AI/ML] [ Article | Bib | Errota | Appendix | Code | Poster ]
[C5] Unsupervised learning by a “softened” correlation game: duality and convergence.
Kyle Luther*, Runzhe Yang* and Sebastian Seung (invited paper).
In proceedings of the 53rd Asilomar Conference on Signals, Systems, and Computers (ACSSC 2019), Pacific Grove, USA, November 2019 .
[ AI/ML] [ Article | Bib ]
[C4] Imitation refinement for x-ray diffraction signal processing.
Junwen Bai, Zihang Lai, Runzhe Yang, Yexiang Xue, John Gregoire and Carla Gomes.
In proceedings of the 2019 International Conference on Acoustics, Speech, and Signal Processing (ICASSP 2019), Brighton, UK, May 2019.
[ AI/ML] [ Article | Bib ]

[A1] Mitochondrial size gradients in cortical neurons suggested by 3D electron microscopy.
Nicholas L. Turner, Runzhe Yang, Agata Foryciarz, Kisuk Lee, William Silversmith, William Wong, Jingpeng Wu, Sven Dorkenwald, T. L. Lewis, Yusuke Hirabayashi, Franck Polleux, Nuno da Costa, R. Clay Reid, H. Sebastian Seung
Poster at the conference of Society for Neuroscience (SfN 2018), San Diego, CA, USA, November 2018.
[ Neuro] [ Abstract | Poster ]

[M3] Imitation refinement.
Runzhe Yang*, Junwen Bai* (equal authorship), Yexiang Xue, John Gregoire and Carla Gomes. May 2018.
[ AI/ML] [ ArXiv | Bib | Code]

[M1] Pedagogical value-aligned crowdsourcing.
Runzhe Yang, Yexiang Xue and Carla Gomes. December 2017.
[ Crowdsourcing] [ Article1 | Article2 | Appendix | Code]
[C3] Affordable on-line dialogue policy learning.
Runzhe Yang*, Cheng Chang* (equal authorship), Lu Chen, Xiang Zhou and Kai Yu.
In proceedings of the 2017 Conference on Empirical Methods in Natural Language Processing (EMNLP 2017), Copenhagen, Denmark, September 2017.
[ AI/ML] [ NLP] [ Article | Bib | Appendix ]
[C2] Agent-aware dropout DQN for safe and efficient on-line dialogue policy learning.
Lu Chen, Xiang Zhou, Cheng Chang, Runzhe Yang and Kai Yu.
In proceedings of the 2017 Conference on Empirical Methods in Natural Language Processing (EMNLP 2017), Copenhagen, Denmark, September 2017.
[ AI/ML] [ NLP] [ Article | Bib | Appendix ]
[C1] On-line dialogue policy learning with companion teaching.
Lu Chen, Runzhe Yang, Cheng Chang, Zihao Ye, Xiang Zhou and Kai Yu.
In proceedings of the 15th Conference of the European Chapter of the Association for Computational Linguistics (EACL 2017), Valencia, Spain, April 2017.
[ AI/ML] [ NLP] [ Article | Bib | Poster ]